Ivory Coast: New prime minister named

ABIDJAN, Ivory Coast (AP) — President Alassane Ouattara has tapped Foreign Minister Daniel Kablan Duncan to serve as prime minister in a new government one week after the surprise dissolution of cabinet.

The appointment of Duncan, a member of the PDCI party of former President Henri Konan Bedie, was announced at a press conference Wednesday by Amadou Gon Coulibaly, general secretary of the presidency.

Ouattara dissolved the cabinet last week over a feud between his political party and the PDCI over proposed changes to the country’s marriage law.

The PDCI supported Ouattara in the November 2010 runoff election in exchange for the prime minister’s post, helping him defeat incumbent President Laurent Gbagbo. Gbagbo’s refusal to cede office led to five months of violence that claimed at least 3,000 lives before Ouattara’s forces won.

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Scott Derrickson to direct feature adaptation of hit video game “Deus Ex: Human Revolution”

LOS ANGELES (TheWrap.com) – Scott Derrickson (“Sinister,” “The Exorcism of Emily Rose“) has signed on to direct the big screen adaptation of the hit Square Enix video game, “Deus Ex: Human Revolution,” for CBS Films, the company announced on Thursday.

Derrickson will also write the screenplay for the film with C. Robert Cargill (“Sinister.”)

Roy Lee and Adrian Askarieh are attached to produce the film, with John P. Middleton serving as the executive producer.

Set in the near future, when dramatic advances in science, specifically human augmentation, have triggered a technological renaissance, “Deus Ex: Human Revolution” follows Adam Jensen, an ex-SWAT security specialist who must embrace mechanical augments in order to unravel a global conspiracy.

“‘Deus Ex’ is a phenomenal cyberpunk game with soul and intelligence,” said Derrickson. “By combining amazing action and tension with big, philosophical ideas, ‘Deus Ex‘ is smart, ballsy, and will make one hell of a movie. Cargill and I can’t wait to bring it to the big screen.”

The “Deus Ex” franchise was originally introduced in June 2000. Its latest entry, “Deus Ex: Human Revolution,” launched in 2011, ranked number one across global sales charts and earned over 100 industry awards.

Developed by Eidos-Montréal and published by Square Enix, “Deus Ex: Human Revolution” will serve as the primary template for the film.

Derrickson and Cargill, pictured above, are represented by WME and managed by Brillstein Entertainment Partners.

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“Hitchcock” trains lens on the love story of Alfred and Alma

NEW YORK (Reuters) – She won Oscar gold for her uncanny performance as Britain’s Queen Elizabeth, but Helen Mirren‘s latest portrayal finds her as the power behind the throne — or, more precisely, the director’s chair.

In “Hitchcock,” Mirren stars opposite Anthony Hopkins as legendary director Alfred Hitchcock’s devoted wife Alma Reville, and early buzz has her a contender for another Oscar nomination.

The film, which opens in limited release on Friday, explores the domestic life of one of Hollywood‘s most iconic and revered directors, set during the days of his struggle to put the ground-breaking 1960 classic, “Psycho” on the silver screen.

Toggling back and forth between his on-set battles with censors and his cast including Janet Leigh (Scarlett Johansson), Vera Miles (Jessica Biel) and Tony Perkins (James D’Arcy), and his strained relationship with Alma as she copes with his well-documented obsession with his ravishing leading ladies, “Hitchcock” treats film fans to a glimpse of bygone Hollywood.

But it paints a more nuanced and sympathetic portrait of the director Hopkins called “a damaged man” than the recent television film “The Girl,” which dramatized the hell Hitchcock put Tippi Hedren through during filming of “The Birds.”

“It’s a great role,” Mirren said of Alma, a film editor and assistant director in her own right who ceded the spotlight to her husband, but as the film makes clear was involved in virtually every aspect of his films and even re-cut “Psycho” into the masterpiece it is known as today.

“So, you don’t turn that down,” she told Reuters.

Having won her Oscar as one of the world’s most famous women, Mirren said she finds herself drawn to “the ones I don’t know anything about, like Alma. Those are the most fun.”

With little to go on, Mirren said she turned to the 2003 book “Alma Hitchcock: The Woman Behind the Man,” by the couple’s daughter Patricia, who also acted in several Hitchcock films.

“I’m not that much of a film buff that I knew about Alma, and I had no idea about Hitchcock‘s private life,” she said, adding the book aimed “to bring her mother out of the shadows.”

HITCH THE BRAND

By all accounts making the movie about the movies was a joy, with Mirren and Hopkins co-starring in their first film together under first-time director Sacha Gervasi (“Anvil: The Story of Anvil”), who fixed a script that had made the rounds.

Hopkins described it as the “most fun” since his Oscar-winning role in the thriller “Silence of the Lambs.”

Mirren recalled rushing off to work each day: “I couldn’t wait.” And it helped that the actors have the same approach.

“There’s no mystery to it … They talk about chemistry, and Helen agrees with me, there’s no such thing. You know your part, she knows hers, and off you go, hope it works,” Hopkins said.

But Mirren and Hopkins, who is also being touted for an Oscar nomination, parted ways when speculating on how the auteur director, who never won an Oscar during five decades of work, would have fared in the Hollywood of today.

“He would have despaired,” Hopkins said. “It would have been anathema to him. That kind of artistry is gone.”

Corporate control means “you have eight or nine producers on the set, everyone’s got a say in the scripts, and even craft services!”

But Mirren differed, imagining “he’d do brilliantly well.”

“He was a great salesman, and the Hollywood of today is so much about being a salesman and being able to sell yourself as a brand,” she explained. “He did that brilliantly. I think the two of them sold Hitch. Hitch was the faceman, he was the brand.”

“Also,” she added, “his filmmaking techniques would be incredibly successful,” given the technological advances since Hitchcock’s death in 1980.

Hitchcock was on a roll in his early 60s, with his “Psycho” follow-up, the shocking thriller “The Birds” becoming a hit and a much-loved classic. But none of the handful of films he made afterward attained their iconic status.

Mirren, 67, by contrast, truly hit her stride during her 40s, despite a steady two-decade career by that point.

Starting with the TV show “Prime Suspect” to the films “Gosford Park,” “The Queen” and “The Last Station,” she racked up four Oscar nominations and a mantel full of Emmys, which raises a question about the validity of complaints that Hollywood has no use for actresses over 40.

“I think what has changed is, the world around has changed,” Mirren said when reflecting on her success and acclaim.

“I was lucky that I hit my 40s just as the world around me was changing. Twenty years before I never would have been cast in ‘Prime Suspect’ because there were no women inspectors.”

And so, she looks forward.

“As I’ve carried on, my God, 20 years ago it was inconceivable that you’d have a female president of the United States,” she said.

“Now, the next president of America may well be a woman, and if there is a female president, that means that if a movie comes along, and there’s the president of America …” She laughs.

“You know what I mean?”

(Editing by Christine Kearney)

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U.S. soldier accused of Iraq shooting “psychotic”: doctor

TACOMA (Reuters) – A U.S. soldier accused of killing five fellow servicemen at a military combat stress center in Baghdad in 2009 was psychotic and suffered from post-traumatic stress disorder during the shooting frenzy, a top U.S. forensic psychiatrist testified on Tuesday.

Sergeant John Russell, 48, is accused of going on a shooting spree at Camp Liberty, near the Baghdad airport, in an assault the military said at the time could have been triggered by combat stress.

Russell, of the 54th Engineer Battalion based in Bamberg, Germany, faces five charges of premeditated murder, one charge of aggravated assault and one charge of attempted murder in connection with the May 2009 shootings.

Six months ago, he was ordered to stand trial in a military court that has the power to sentence him to death, if he is convicted.

Russell’s civilian attorney, James Culp, entered no plea at an arraignment on Monday at a military base in Washington state. Russell’s court martial is tentatively set for mid-March and could last four to five weeks, attorneys told Reuters on Tuesday.

In a second day of hearings to discuss Russell’s state of mind at the time of the shooting and establish what evidence or testimony to admit at the court martial, Robert Sadoff, a University of Pennsylvania forensic psychiatry expert, gave the opinion that Russell was suffering from post-traumatic stress disorder.

Russell has “dissociative disorder,” or a lack of memory about the shootings, said Sadoff, who examined Russell for a total of 20 hours after the shootings. “He cannot remember. It’s a legitimate disorder. He also has post-traumatic stress disorder.”

Sadoff, a veteran of 10,000 criminal cases added: “It’s a matter of what’s going on in this man’s mind. He was psychotic. He was not dealing with reality. That’s what psychosis is.”

If the defense can persuade a jury that Russell was not in control of his actions, it may be able to argue that he is not legally responsible and could spare him from the death penalty, if convicted.

During Tuesday’s hearing, Culp sought authority from Judge Colonel David Conn to hire a forensic hypnotist to unlock Russell’s buried memories and conduct a specialized magnetic resonance imaging (MRI) test to measure Russell’s “mild diffused brain atrophy”, which Culp argues played a part in his behavior.

This would help diagnose “the extent of brain damage as it relates to criminal responsibility,” Culp said.

Army prosecutors urged the judge to decline. Major Dan Mazzone, one of four Army attorneys prosecuting the case, told the judge that an Army medical review already indicated that Russell’s brain atrophy was typical of a man his age and further testing is an unnecessary expense to the Army.

“The bottom line, this is just not necessary. It’s something the government should not be entitled to fund,” Mazzone said.

The judge is set to rule on the matter over the next few days.

The proceedings, held at Joint Base Lewis-McChord near Tacoma, Washington, come at a sensitive time for the Army, which is in the process of deciding how to prosecute Staff Sergeant Robert Bales, a soldier accused of killing Afghan villagers in cold blood earlier this year.

A two-week hearing at Lewis-McChord to establish if there is sufficient evidence to send Bales to a court martial wrapped up last week after harrowing testimony from Afghan adults and children wounded in the attack.

Bales’ civilian defense lawyers have also suggested he was suffering from post-traumatic stress disorder.

On Monday, Russell’s attorney outlined a defense based on his declining mental state.

Russell suffered from depression, thoughts of suicide, anxiety and stress from multiple deployments, and suffered “at least one traumatic experience involving civilian casualties” and “mass grave sites” while serving in Bosnia and Kosovo during 1998 and 1999, Culp said in presenting arguments to the judge after the arraignment.

(Reporting by Bill Rigby; Editing by Lisa Shumaker)

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Asia stocks fall after Greece aid delayed

BANGKOK (AP) — Asian stock markets were mostly lower Wednesday, shedding morning gains after European Union officials failed to release a loan payment to debt-mired Greece and postposed further action until next week.

European finance ministers adjourned a meeting in Brussels without granting Greece the next installment of an emergency bailout loan that has been on hold for months. The €31.5 billion ($ 40 billion) loan is needed so that Athens can pay its bills and avoid running out of cash.

The aid is being delayed until officials can resolve a dispute over whether to give Greece an extra two years to get to a point where it can independently raise funds on bond markets. Greece has been locked out of the international long-term debt market since 2010 and thus relies on rescue loans.

The reform program attached to the bailout was to steadily reduce Greece’s debt to 120 percent of its annual gross domestic product by a 2020 deadline. But some officials say the deadline may have been too ambitious and that Greece needs two more years.

South Korea’s Kospi fell 0.4 percent to 1,882.62 after a higher open. Meanwhile, Australia’s S&P/ASX 200 fell further into negative territory, down 0.3 percent at 4,371.10. Benchmarks in Thailand, New Zealand and Taiwan also were lower.

But Japan’s Nikkei 225 index rose 0.4 percent to 9,178.05, with export shares enjoying the benefits of a weakened yen. Hong Kong‘s Hang Seng added 0.2 percent to 21,272.48. Benchmarks in India and the Philippines also rose.

Mainland China‘s Shanghai Composite Index briefly dipped below 2,000, an important psychological mark. The benchmark hasn’t gone above 2,100 since July 6.

The benchmark “has been hovering around 2,000 for such a long time that investors have lost interest,” said Francis Lun, managing director of Lyncean Holdings in Hong Kong. “The weakness in China‘s market is dragging down the Hong Kong market.”

The losses reflected disappointment among investors hoping to see changes in how the stock market is run now that China has new leaders. But reforms have so far not materialized.

“There has been too much resistance to cleaning up the malpractice” in mainland Chinese markets, Lun said. “Investors have lost confidence.”

Among individual stocks, Japanese snack food maker Calbee dropped 3.7 percent after announcing the recall of millions of bags of potato chips due to possible contamination with glass fragments.

Wall Street stocks finished roughly flat Tuesday after a warning from the Federal Reserve chairman about the “fiscal cliff” of tax increases and government spending cuts set to take effect Jan. 1.

The Dow Jones industrial average fell 0.1 percent to 12,788.51. The Standard & Poor’s 500 index rose 0.1 percent to 1,387.81. The Nasdaq composite index inched up to 2,916.68.

In a speech in New York on Tuesday, Bernanke urged Congress and the Obama administration to strike a budget deal to avert the combination of tax increases and spending cuts that will automatically take effect in January if nothing is done.

“This overshadowed some positive economic data which came in the form of better-than-expected housing starts,” said Stan Shamu of IG Markets in Melbourne in a market commentary.

Benchmark oil for January delivery was down 1 cent at $ 86.74 per barrel in electronic trading on the New York Mercantile Exchange. The contract fell $ 2.53 to close at $ 86.75 a barrel on Tuesday, falling sharply after signs that Israel and Hamas are close to putting a halt to fighting that has lasted nearly a week.

In currencies, the dollar rose to 81.79 yen from 81.71 yen late Tuesday in New York. The euro fell to $ 1.2747 from $ 1.2807.

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AP Exclusive: Syrian rebels seize base, arms trove

BASE OF THE 46TH REGIMENT, Syria (AP) — After a nearly two-month siege, Syrian rebels overwhelmed a large military base in the north of the country and made off with tanks, armored vehicles and truckloads of munitions that rebel leaders say will give them a boost in the fight against President Bashar Assad‘s army.

The rebel capture of the base of the Syrian army’s 46th Regiment is a sharp blow to the government’s efforts to roll back rebels gains and shows a rising level of organization among opposition forces.

More important than the base’s fall, however, are the weapons the rebels found inside.

At a rebel base where the much of the haul was taken after the weekend victory, rebel fighters unloaded half a dozen large trucks piled high with green boxes full of mortars, artillery shells, rockets and rifles taken from the base. Parked nearby were five tanks, two armored vehicles, two rocket launchers and two heavy-caliber artillery cannons.

Around 20 Syrian soldiers captured in the battle were put to work carrying munitions boxes, barefoot and stripped to the waist. Rebels refused to let reporters talk to them or see where they were being held.

“There has never been a battle before with this much booty,” said Gen. Ahmad al-Faj of the rebels Joint Command, a grouping of rebel brigades that was involved in the siege. Speaking on Monday at the rebel base, set up in a former customs office at Syria’s Bab al-Hawa border crossing with Turkey, he said the haul would be distributed among the brigades.

For months, Syria’s rebels have gradually been destroying government checkpoints and taking over towns in the northern provinces of Idlib and Aleppo along the Turkish border.

Rebel fighters say that weapons seized in such battles have been essential to their transformation from ragtag brigades into forces capable of challenging Assad’s professional army. Cross-border arms smuggling from Turkey and Iraq has also played a role, although the most common complaint among rebel fighters is that they lack ammunition and heavy weapons, munitions and anti-aircraft weapons to fight Assad’s air force.

It is unclear how many government bases the rebels have overrun during the 20-month conflict, mostly because they rarely try to hold captured facilities. Staying in the captured bases would make them sitting ducks for regime airstrikes.

“Their strategy is to hit and run,” said Elias Hanna, a retired Lebanese army general and Beirut-based strategic analyst. “They’re trying to hurt the regime where it hurts by bisecting and compartmentalizing Syria in order to dilute the regime’s power.”

The 46th Regiment was a major pillar of the government’s force near the northern city of Aleppo, Syria’s economic hub, and its fall cuts a major supply line to the regime’s army, Hanna said. Government forces have been battling rebels for months over control of Aleppo.

“It’s a tactical turning point that may lead to a strategic shift,” he said.

At the 46th Regiment’s base, about 25 kilometers (15 miles) west of Aleppo, the main three-story command building showed signs of the battle — its walls punctured apparently from rebel rocket attacks. The smaller barracks buildings scattered around the compound, about 2.6 square kilometers (1 square mile) in size, had been looted, with mattresses overturned. A number of buildings had been torched.

Reporters from The Associated Press who visited the base late Monday saw no trace of the government troops who had been defending it — other than the dead bodies of seven soldiers.

Two of them, in camouflage uniforms, lay outside the command building. One of them was missing his head, apparently blown off in an explosion.

The rest were in a nearby clinic. Four dead soldiers were on stretchers set on the floor, one with a large gash in his arm, another with what appeared to be a large shrapnel hole in the back of his head. The last lay on a gurney in another room, his arms and legs bandaged, a bullet hole in his cheek and a splatter of blood on the wall and ceiling behind him as if he had been shot where he lay.

It could not be determined how or when the soldiers had been killed.

The final assault that took the base came after more than 50 days of siege that left the soldiers inside demoralized, according to fighters who took part.

Working together and communicating by radio, a number of different rebels groups divided up the area surrounding the base and each cut the regime’s supply lines, said Abdullah Qadi, a rebel field commander. Over the course of the siege, dozens of soldiers defected, some telling the rebels that those inside were short of food, Qadi said.

The rebels decided to attack Saturday afternoon when they felt the soldiers inside were weak and the rebels had enough ammunition to finish the battle, Qadi said. The battle was over by nightfall on Sunday. Seven rebel fighters were killed in the battle, said al-Faj of the rebels’ Joint Command. Other rebel leaders gave similar numbers.

It remains unclear how many soldiers remained in the base when the rebels launched their attack and what happened to them.

Al-Faj said all soldiers inside were either killed or captured. He said he didn’t know how many were killed, but that the rebels had taken about 50 prisoners, all of whom would be tried in a rebel court. Aside from the 20 prisoners seen at the rebel’s Bab al-Hawa base, the AP was unable to see any other captured soldiers.

The Syrian government does not respond to requests for comment on military affairs and said nothing about the base’s capture. It says the rebels are terrorists backed by foreign powers that seek to destroy the country.

Disorganization has plagued the Syrian opposition since the start of the anti-Assad uprising in March 2011, with exile groups pleading for international help even when they have no control over those fighting inside of Syria.

A newly formed Syrian opposition coalition received a boost Tuesday, when Britain officially recognized it as the sole representative of the Syrian people.

The National Coalition of the Syrian Revolutionary and Opposition Forces was formed in the Gulf nation of Qatar on Oct. 11 under pressure from the United States for a stronger, more united opposition body to serve as a counterweight to more extremist forces.

British Foreign Secretary William Hague said Tuesday the body’s members gave assurances to be a “moderate political force committed to democracy” and that the West must “support them and deny space to extremist groups.”

The United States and the European Union have both spoken well of the body but stopped short of offering it full recognition.

Key to the body’s success will be its ability to build ties with the disparate rebel groups fighting inside Syria. Many rebel leaders say they don’t recognize the new body, and a group of extremist Islamist factions on Monday rejected it, announcing that they had formed an “Islamic state” in Aleppo.

Anti-regime activists say nearly 40,000 people have been killed since Syria’s crisis started 20 months ago.

___

Associated Press write Elizabeth Kennedy contributed reporting from Beirut, Lebanon.

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AP Exclusive: Syrian rebels seize base, arms trove

BASE OF THE 46TH REGIMENT, Syria (AP) — After a nearly two-month siege, Syrian rebels overwhelmed a large military base in the north of the country and made off with tanks, armored vehicles and truckloads of munitions that rebel leaders say will give them a boost in the fight against President Bashar Assad‘s army.

The rebel capture of the base of the Syrian army’s 46th Regiment is a sharp blow to the government’s efforts to roll back rebels gains and shows a rising level of organization among opposition forces.

More important than the base’s fall, however, are the weapons the rebels found inside.

At a rebel base where the much of the haul was taken after the weekend victory, rebel fighters unloaded half a dozen large trucks piled high with green boxes full of mortars, artillery shells, rockets and rifles taken from the base. Parked nearby were five tanks, two armored vehicles, two rocket launchers and two heavy-caliber artillery cannons.

Around 20 Syrian soldiers captured in the battle were put to work carrying munitions boxes, barefoot and stripped to the waist. Rebels refused to let reporters talk to them or see where they were being held.

“There has never been a battle before with this much booty,” said Gen. Ahmad al-Faj of the rebels Joint Command, a grouping of rebel brigades that was involved in the siege. Speaking on Monday at the rebel base, set up in a former customs office at Syria’s Bab al-Hawa border crossing with Turkey, he said the haul would be distributed among the brigades.

For months, Syria’s rebels have gradually been destroying government checkpoints and taking over towns in the northern provinces of Idlib and Aleppo along the Turkish border.

Rebel fighters say that weapons seized in such battles have been essential to their transformation from ragtag brigades into forces capable of challenging Assad’s professional army. Cross-border arms smuggling from Turkey and Iraq has also played a role, although the most common complaint among rebel fighters is that they lack ammunition and heavy weapons, munitions and anti-aircraft weapons to fight Assad’s air force.

It is unclear how many government bases the rebels have overrun during the 20-month conflict, mostly because they rarely try to hold captured facilities. Staying in the captured bases would make them sitting ducks for regime airstrikes.

“Their strategy is to hit and run,” said Elias Hanna, a retired Lebanese army general and Beirut-based strategic analyst. “They’re trying to hurt the regime where it hurts by bisecting and compartmentalizing Syria in order to dilute the regime’s power.”

The 46th Regiment was a major pillar of the government’s force near the northern city of Aleppo, Syria’s economic hub, and its fall cuts a major supply line to the regime’s army, Hanna said. Government forces have been battling rebels for months over control of Aleppo.

“It’s a tactical turning point that may lead to a strategic shift,” he said.

At the 46th Regiment’s base, about 25 kilometers (15 miles) west of Aleppo, the main three-story command building showed signs of the battle — its walls punctured apparently from rebel rocket attacks. The smaller barracks buildings scattered around the compound, about 2.6 square kilometers (1 square mile) in size, had been looted, with mattresses overturned. A number of buildings had been torched.

Reporters from The Associated Press who visited the base late Monday saw no trace of the government troops who had been defending it — other than the dead bodies of seven soldiers.

Two of them, in camouflage uniforms, lay outside the command building. One of them was missing his head, apparently blown off in an explosion.

The rest were in a nearby clinic. Four dead soldiers were on stretchers set on the floor, one with a large gash in his arm, another with what appeared to be a large shrapnel hole in the back of his head. The last lay on a gurney in another room, his arms and legs bandaged, a bullet hole in his cheek and a splatter of blood on the wall and ceiling behind him as if he had been shot where he lay.

It could not be determined how or when the soldiers had been killed.

The final assault that took the base came after more than 50 days of siege that left the soldiers inside demoralized, according to fighters who took part.

Working together and communicating by radio, a number of different rebels groups divided up the area surrounding the base and each cut the regime’s supply lines, said Abdullah Qadi, a rebel field commander. Over the course of the siege, dozens of soldiers defected, some telling the rebels that those inside were short of food, Qadi said.

The rebels decided to attack Saturday afternoon when they felt the soldiers inside were weak and the rebels had enough ammunition to finish the battle, Qadi said. The battle was over by nightfall on Sunday. Seven rebel fighters were killed in the battle, said al-Faj of the rebels’ Joint Command. Other rebel leaders gave similar numbers.

It remains unclear how many soldiers remained in the base when the rebels launched their attack and what happened to them.

Al-Faj said all soldiers inside were either killed or captured. He said he didn’t know how many were killed, but that the rebels had taken about 50 prisoners, all of whom would be tried in a rebel court. Aside from the 20 prisoners seen at the rebel’s Bab al-Hawa base, the AP was unable to see any other captured soldiers.

The Syrian government does not respond to requests for comment on military affairs and said nothing about the base’s capture. It says the rebels are terrorists backed by foreign powers that seek to destroy the country.

Disorganization has plagued the Syrian opposition since the start of the anti-Assad uprising in March 2011, with exile groups pleading for international help even when they have no control over those fighting inside of Syria.

A newly formed Syrian opposition coalition received a boost Tuesday, when Britain officially recognized it as the sole representative of the Syrian people.

The National Coalition of the Syrian Revolutionary and Opposition Forces was formed in the Gulf nation of Qatar on Oct. 11 under pressure from the United States for a stronger, more united opposition body to serve as a counterweight to more extremist forces.

British Foreign Secretary William Hague said Tuesday the body’s members gave assurances to be a “moderate political force committed to democracy” and that the West must “support them and deny space to extremist groups.”

The United States and the European Union have both spoken well of the body but stopped short of offering it full recognition.

Key to the body’s success will be its ability to build ties with the disparate rebel groups fighting inside Syria. Many rebel leaders say they don’t recognize the new body, and a group of extremist Islamist factions on Monday rejected it, announcing that they had formed an “Islamic state” in Aleppo.

Anti-regime activists say nearly 40,000 people have been killed since Syria’s crisis started 20 months ago.

___

Associated Press write Elizabeth Kennedy contributed reporting from Beirut, Lebanon.

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Review: Gift guide to full-size tablets

NEW YORK (AP) — Tablets are at the top of many wish lists this holiday season. But what to get? The choice used to be pretty limited, with the iPad dominating the latecomers. But this year, the field is more even, as tablets from Apple‘s competitors have matured. In addition, Google and Microsoft are diving in with their own tablets, providing more choice.

The first step in the buying process is to decide on the size of the tablet. They fall into two rough categories: the full-sized tablet, pioneered by the iPad, and the half-size tablet, epitomized by the Kindle Fire.

Full-sized tablets, which generally have screens measuring about 10 inches on the diagonal, are better for surfing websites designed for PCs, and far better when it comes to displaying magazines and documents. Overall, they go further toward replacing a laptop. They cost $ 400 and up.

Half-sized tablets, which have screens measuring roughly 7 inches on the diagonal, are cheaper and lighter, but just as good as full-sized tablets for e-book reading. It’s an excellent first computing device for a kid, or a gentle nudge into the digital world for an older adult with little computing experience. This year’s crop costs $ 199 and up, but last year’s models are available for less.

If you’ve settled on a large tablet, here are some top choices. A review of smaller tablets ran Monday.

— Apple iPad, fourth generation (starts at $ 499)

Apple usually updates the iPad once a year, so it was a surprise when it dropped a new model in October, with a faster processor and the new “Lightning” connection and charging port, replacing the wide port inherited from the iPod. Like the third-generation iPad launched in March it has an ultra-high-resolution “Retina” screen. The model’s resolution of 2,048 by 1,536 pixels is only surpassed by the Google Nexus 10.

That means the current iPad is two generations ahead of the iPad 2 that was on sale last holiday season. It packs enough improvements to make the upgrade worth it. The iPad 2 is still on sale for $ 100 less, but it’s not a very good value for the money: if $ 400 is all you can spend, there are better tablets out there than the iPad 2.

While other tablets are starting to approach it in terms of hardware, the iPad still enjoys the best support by far from third parties, both in terms of quality applications and accessories like cases.

One caveat: the base model of the iPad has only 16 gigabytes of storage, which fills up fast these days. The thoughtful giver goes for at least a 32-gigabyte model, for $ 100 more.

Other than that, there are few downsides to the iPad: no one will frown when opening this package.

— Barnes & Noble Nook HD+ (starts at $ 269)

For a book store, Barnes & Noble makes some amazing tablets. The HD+ is its first model that approaches the iPad in size, with a screen that’s 9 inches on the diagonal. That makes it slightly smaller than the iPad, and the resolution is lower as well, but still very respectable. At 1,920 by 1,280 pixels, it can show more detail than a living-room HDTV.

The Nook is family-friendly too. You can create user accounts and restrict them from certain content, so there’s less risk that your kids will stumble on your copy of “Fifty Shades of Grey.”

Like the basic iPad, the basic Nook HD+ comes with just 16 gigabytes of storage memory, but it can be expanded with a microSD memory card. That means another 32 gigabytes will cost you just $ 25 — a good deal.

But the Nook is the least versatile tablet in our roundup. The number of apps available is small, and it’s focused on Barnes & Noble content like e-books, magazines and movies. It doesn’t have any cameras, while the competitors have two each. It’s best for someone who’s likely to stick to media consumption, and doesn’t need the latest apps and games.

— Samsung Galaxy Note 10.1 (starts at $ 499)

If the Nook is for the avid reader or movie watcher, the Galaxy Note 10.1 is for the creative type. It’s the only tablet in our roundup that comes with a “pen” that can be used to write and draw on the screen. In our test, this worked well, though the number of apps that take advantage of the pen is still small. (Other tablets, like the iPad, only respond to finger-like objects, so third-party styluses for them are of necessity thick and clumsy.)

The Note 10.1 runs Google‘s Android software, giving it access to a wide array of apps originally written for smartphones. The selection is not on par with the iPad’s but better than other alternatives.

The Note’s screen falls into the low-resolution category, sporting 1,280 by 800 pixels. That’s a third of what the iPad musters.

Like the Nook, the Note 10.1′s storage memory can be expanded with cards.

The Note’s appeal is somewhat niche, but it could be just the thing for the budding or established artist.

— Microsoft Surface (starts at $ 499)

Microsoft’s first tablet seems at first like a throwback to the first iPad. It’s thick, heavy and rugged. But it’s really doesn’t have much in common with the first iPad or any Apple- or Google-powered tablet. It runs Windows RT, a version of Windows 8 adapted for tablets. It comes with a version of Microsoft’s Office suite and the ability to connect to wireless printers and some other peripherals, like USB drives. The covers for it have functional keyboard printed on the inside.

The screen resolution is 1,366 by 768 pixels, placing it in the low-resolution category.

The Surface screams “work, work, work.” It’s the tablet for those who are wedded to Word and want to take their writing on the go.

One thing to note about the Surface: the basic model starts out with “32 gigabytes” of memory, but of that, only 16 gigabytes are available to the user. It accepts memory cards of up to 64 gigabytes, however, so expanding the memory is cheap.

Note that even though it runs Windows, the Surface doesn’t run standard Windows applications. It will run only programs specifically adapted for Windows RT. The selection is, for now, quite limited.

— Asus Vivo Tab RT (starts at $ 599 with a dock)

Asus has a quality line of Android tablets they call “Transformer” because they dock into a keyboard with an extra battery. The combination folds up just like a small laptop and has excellent battery life. The Vivo Tab RT essentially takes a Transformer and stuffs it with Windows RT instead of Android.

The tablet part is smaller and thinner than the Surface. Together with the keyboard, it makes for a familiar little setup: a tiny laptop running Windows. Like the Surface, it has a memory card slot and a USB port. The screen resolution is the same.

The Vivo Tab is a good tool for those who want to get some work done on the commute or plane, or those who can’t decide if they want a laptop or a tablet.

— Google Nexus 10 (starts at $ 399)

This is Google’s first full-size tablet and the only tablet from any manufacturer that beats the screen resolution of the iPad. It boasts 2,560 by 1,600 pixels, a third more than the fourth-generation iPad.

It’s also the only tablet in this roundup that has speakers on either side of the screen when it’s held horizontally, making for good stereo reproduction when you’re watching movies. It has a grippy, rubberized back and widely rounded corners. There’s no memory card slot or an option for a cellular modem.

The array of third-party software is wide, just as it is for the Note 10.1. Most people don’t associate Google with online books, music or movies, so it may feel odd that the Nexus steers buyers to Google’s Play store. Of course, given the open nature of Google’s Android operating system, there are apps available for other entertainment stores, including Amazon’s, and for streaming services like Netflix.

The Nexus 10 is a snappy performer, and among the iPad’s competitors, it comes the closest to matching the versatility of Apple products.

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Peter Svensson can be reached at http://www.twitter.com/petersvensson

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“Twilight” sendoff starts with huge $341 million worldwide

(Reuters) – The “Twilight” vampire saga‘s final chapter debuted with a massive $ 341 million in global movie ticket sales as devoted fans bid farewell to blood-sucking spouses Bella and Edward and one of Hollywood‘s biggest franchises.

“The Twilight Saga: Breaking Dawn – Part 2″ earned an estimated $ 141 million in the United States and Canada over the weekend, falling slightly short of a record for the supernatural romance series about a human-vampire-werewolf love triangle.

The total, which includes sales from late night Thursday through Sunday, ranked as the eight biggest domestic film debut of all time. Late-night Thursday screenings comprised $ 30.4 million of the $ 141 million total.

Fan fever for the fifth “Twilight” movie raged high around the world. “Breaking Dawn – Part 2″ rang up sales of $ 199.6 million from Thursday to Sunday at theaters in 61 countries for a worldwide total of $ 341 million, distributor Summit Entertainment said on Sunday.

The earlier “Twilight” films pulled in a combined $ 2.5 billion at global box offices over a four-year run. The success lifted tiny studio Summit Entertainment into Hollywood‘s big leagues and paved the way for its $ 412 million acquisition in January by Lions Gate Entertainment.

“New Moon” scored the biggest debut of the series, grossing $ 142.8 million over its first three days in 2009.

The movies based on a series of best-selling young adult books by Stephenie Meyer ignited a pop culture infatuation with blood-sucking vampires and werewolves. The films star Kristen Stewart as human-turned-vampire Bella Swan, Robert Pattinson as her vampire love Edward Cullen, and Taylor Lautner as werewolf Jacob Black, who competes for Bella’s affection.

Summit spent $ 120 million to produce “Breaking Dawn – Part 2,” which concludes the tale with newly turned vampire Bella and husband Edward in a high-stakes battle to protect their half-human, half-vampire daughter from an ancient vampire clan. The couple enlist the extended Cullen family in their fight.

Fans of the series, mostly teen girls nicknamed “Twi-hards,” embraced the final film, which includes a surprise twist that was not in the final book. Audiences polled by CinemaScore awarded the movie an “A” grade, with an “A+” from filmgoers under age 25, according to Summit. Critics were less supportive. Fifty-one percent of reviews collected on the Rotten Tomatoes website were positive.

Summit Entertainment‘s president of domestic distribution Richie Fay said though the vast majority of the audience was female, he expected more male viewers than for previous “Twilight” films.

“The male audience has increased a good bit, and the ratings among males are higher I think in part to the action in the film,” he said.

Author Meyer has not ruled out the possibility of more stories in the vampire-werewolf universe but said she has closed the chapter on the Cullens.

Hollywood is eager to fill the void after the success of “Twilight” highlighted the power of young adult stories on the big screen. Studios are bringing at least four new films based on popular young adult novels to theaters next year as well as the sequel to the newest teen movie sensation, “The Hunger Games.

The “Twilight” excitement eclipsed all other movies over the weekend. Last week’s winner, James Bond movie “Skyfall” finished in second place with $ 41.5 million at North American (U.S. and Canadian) theaters.

“Skyfall” is now the highest-grossing Bond movie to date with a global total of over $ 669 million, surpassing the $ 599 million taken in by “Casino Royale” in 2006.

“Skyfall” also propelled distributer Sony Pictures Entertainment to a record year, pushing its worldwide box office total over the $ 4 billion mark.

Historical drama “Lincoln” expanded from a limited opening a week ago and landed in third place with $ 21 million. The movie stars Daniel Day-Lewis as the 16th president near the end of his life as he battles to ban slavery and end the Civil War. The movie is directed by Steven Spielberg and has earned critical praise and awards-season buzz.

In fourth place, Walt Disney Co animated movie “Wreck-It Ralph,” about a videogame character who destroys everything in his path, pulled in $ 18.3 million. Denzel Washington drama “Flight” earned $ 8.6 million and the No. 5 spot.

Elsewhere, romantic comedy “Silver Linings Playbook” brought in $ 458,000 at 16 locations, or an average of $ 28,625 per theater. The film stars Bradley Cooper as a bipolar former teacher just released from a mental institution and Jennifer Lawrence as a young widow he encounters as he tries to put his life back together.

“Silver Linings” won over critics who say it may earn a spot in the Oscar race. The Weinstein Co, the private company that released the movie, will expand the film nationwide beginning on Wednesday, November 21.

Sony Corp’s movie studio distributed “Skyfall.” “Lincoln” was produced by Dreamworks and released by Walt Disney Co. “Flight” was distributed by Paramount Pictures, a unit of Viacom Inc.

(Reporting by Lisa Richwine; Editing by Jackie Frank)

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Those TV Ads for High Cholesterol and Erectile Dysfunction Probably Aren’t Going Away

It has been almost two decades since pharmaceutical manufacturers decided that they might have better luck promoting their products if they bypassed doctors and took their messages straight to consumers. And although the Food and Drug Administration is keeping a wary eye on direct-to-consumer advertising, the practice now appears solidly entrenched. The United States and New Zealand are the only two countries among developed nations that permit direct-to-consumer advertising.

Direct-to-consumer pharmaceutical advertising, or DTC, was never against the law. But pharmaceutical manufacturers began targeting consumers in the 1980s and, in 1999, the FDA clarified the rules on DTC advertising to better protect consumers. Since then, the practice has exploded. According to a 2011 report issued by the Congressional Budget Office, DTC advertising totaled $ 4.7 billion in 2008—about one-quarter of pharmaceutical manufacturers’ promotional budgets.

This year, the FDA launched two new studies on the impact of DTC drug ads and also issued new instructions to manufacturers on how it will review the content of drug ads. However, other attempts to reign in DTC ads, such as through legislation, haven’t progressed very far.

“I think there are a lot of people who want us to pull back from DTC advertising. They think it’s gotten out of hand,” Francis B. Palumbo, professor and executive director of the University of Maryland School of Pharmacy Center on Drugs & Public Policy, told TakePart. But, he adds: “It’s kind of woven into the fabric of American culture now. To pull it back would be very difficult. It’s a question of what would happen if you pulled the plug.”

Some studies suggest that DTC ads aren’t so bad. The ads can educate people, help them start a conversation with their doctors, and even prompt someone to see a doctor when they otherwise might not have. Information contained in the ads may improve patient compliance regarding instructions on how to take a particular drug and how to spot side effects.  

But the ads have generated considerable controversy. Doctor groups tend to dislike the practice, Palumbo says, because consumers demand prescriptions for certain medications they’ve heard about on TV. Sometimes, doctors say,  their patients would benefit more and save money by taking a different medication than the one advertised on television.

RELATED: Beware Rogue Online Pharmacies, FDA Says

“Patients put more pressure on their doctors to prescribe a particular drug when they see it on TV,” Palumbo says.

Other healthcare experts have questioned whether DTC leads to higher drug costs. And, because many DTC ads are for newly approved medications, some critics say the ads expose consumers to unnecessary risks. For example, the drug Vioxx was heavily advertised and sold to millions of people but was later taken off the market because of serious health risks linked to its use.

Certain classes of medications advertised to consumers have triggered considerable controversy, such as advertisements for drugs to treat depression, Palumbo says. While it may be helpful for consumers to know there are treatments for depression, drug companies have been criticized for pitching atypical antipsychotics, a newer class of drugs, for the treatment of depression. Many atypical antipsychotics are costly and carry harsh side effects. Typically, such medications are only prescribed when other treatment options have been exhausted.

RELATED: Americans Struggling to Pay for Prescription Drugs

According to the Congressional Budget Office report, pharmaceutical manufacturers only promote a small set of specific drugs using DTC. The CBO looked at 366 brand-name drugs that were promoted to doctors and other healthcare professionals from 1999 to 2008. Of those drugs, only 73 were advertised directly to consumers. Drug companies spent an average of $ 71 million per drug for a two-year period of DTC advertising.

The CBO found that the average number of prescriptions for newly approved brand-name drugs with DTC advertising was nine times greater than the average number of prescriptions written for newly approved brand-name drugs that weren’t advertised. But pharmaceutical companies are selective about which products are advertised to consumers. They tend to focus on medications for common conditions that affect large numbers of people, like high cholesterol or seasonal allergies.

“When pharmaceutical companies advertise directly to the consumer their sales go up,” Palumbo says. “That’s why they do it. They garner huge sales.”

RELATED: The Most Expensive Prescription Drugs in the U.S.

The FDA is watching the DTC scene carefully. Earlier this year, the agency launched a study examining the impact of “corrective” direct-to-consumer advertising. This is a type of ad that the agency demands of pharmaceutical manufacturers when the company’s initial ad features false or misleading information. One of the best-known examples of a corrective ad was for the birth control pill Yaz. The agency is looking at how corrective ads impact consumer misperceptions about the drug. In other words, do the corrective ads reverse the false impression?

Another FDA study, announced in August, will examine whether consumers understand ads for drugs that have “composite scores.” These are drugs that are advertised for multiple symptoms, such as an allergy drug touted for sneezing, runny nose, watery eyes and wheezing. Such drugs are given a single composite score (encompassing the effectiveness scores for each particular symptom) that shows how effective the drug is compared to another drug. But, the FDA states: “Because most DTC prescription drug ads do not explicitly state that they used composite scores” consumers may not understand the drug’s actual efficacy.

Also this year, the FDA informed pharmaceutical companies that it wants to review DTC ads for new drugs and drugs with new indication before they appear before the public to make sure the ads include all pertinent risk information. The agency will have 45 days to conduct the review

“FDA is under a lot of criticism for that,” Palumbo notes. “FDA is always under-resourced, and the question is whether FDA will get back to the manufacturer in a timely manner. The manufacturers are spending millions of dollars putting out these ads. They want to run them.”

Question: Should FDA tighten the reins on DTC drug ads? Tell us what you think in the comments.

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Shari Roan is an award-winning health writer based in Southern California. She is the author of three books on health and science subjects.

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